Molecular bio-mineralization in decapod crustaceans

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Molecular bio-mineralization in decapod crustaceans

Molecular bio-mineralization in decapod crustaceans

Crustaceans are experts in bio-mineralization, since shedding and hardening their exoskeleton occurs periodically in every molt cycle throughout their life. We use the Australian redclaw crayfish, Cherax quadricarinatus, to study genes related to biomineralization and to answer the main question – what makes crustaceans the undisputed champions in bio-mineralization?

The above studies are done in collaboration with Dr. Shmuel Bentov. In collaboration with Dr. Benjamin Palmer we study reflecting crystals in the eyestalk system.

We use the latest molecular methodologies including in silico, in vitro and in vivo tools to decipher and characterize this complex mechanism that might be harnessed to create biomimetic substances which could be applied in diverse fields such as engineering, biomed and more.

Sponsors and collaborators

Related articles

  • Shaked, S. A., Abehsera, S., Ziegler, A., Bentov, S., Manor, R., Weil, S., Ohana, E., Eichler, J., Aflalo, E. D. and Sagi, A. (2024). A transporter that allows phosphate ions to control the polymorph of exoskeletal calcium carbonate biomineralization. Acta Biomaterialia 2024:02035.
  • Shavit K., Wagner, A., Schertel, L., Farstey, V., Akkaynak, D., Zhang, G., Upcher, A., Sagi, A., Yallapragada, V. J., Haatja, J., and Palmer B. A. (2022) A Tunable Reflector Enabling Crustaceans to See but not be Seen. Science
  • Shaked, S. A., Abehsera, S., Levy, T., Chalifa-Caspi, V. and Sagi, A. 2020. From sporadic single genes to a broader transcriptomic approach: insights into the formation of the biomineralized exoskeleton in decapod crustaceans. Journal of Structural Biology 212: 107612.
  • Bentov, S., Zaslansky, P., Al-Sawalmih, A., Masic, A., Fratzl, P., Sagi, A., Berman, A., and Aichmayer, B. 2012.Enamel-like apatite crown covering amorphous mineral in a crayfish mandible. Nature communications.
  • Abehsera, S., Glazer, L., Tynyakov, J., Plaschkes, I., Chalifa-Caspi, V., Khalaila, I., Aflalo, E. D. and Sagi, A. 2015. Binary gene expression patterning of the molt cycle: The case of chitin metabolism.PLoS ONE, 10(4): e0122602.
  • Abehsera, S., Zaccai S., Mittelman B., Glazer L., Weil S., Khalaila I., Davidov G. Bitton R., Zarivach R., Li, S., Li, F., Xiang, J., Manor R., Aflalo, E.D., and Sagi, A. CPAP3 proteins in the mineralized cuticle of a decapod crustacean. Scientific Reports. 8(1):2430.