The overall goal of our research is based on the hypothesis that dynamic methylation of histone and non-histone proteins plays an important role in the regulation of cellular signal transduction pathways with fundamental effect on human health.
We expect that our research will help to generate a comprehensive view of how intracellular signal transduction pathways, mediated by protein lysine methylation mechanisms, affect chromatin signaling networks and epigenetic programs and how these pathways are linked to the regulation of human diseases. The magnitude of these questions ranging from a single post-translational modification to signaling cascade network mechanisms at chromatin requires the use of multiple converging techniques from biochemical to genomic and proteomic approaches which are all routinely used in our lab. Our research has broad implications for both basic and translational research and will hopefully lead to the characterization of novel molecules that can be used at the bedside of patients for better diagnosis, prognosis and treatment.
