{"id":36,"date":"2023-06-04T12:19:51","date_gmt":"2023-06-04T12:19:51","guid":{"rendered":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/?page_id=36"},"modified":"2024-07-11T13:21:15","modified_gmt":"2024-07-11T13:21:15","slug":"publications","status":"publish","type":"page","link":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/?page_id=36","title":{"rendered":"Publications"},"content":{"rendered":"\n
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Weronika\u00a0Jasinska,\u00a0Mirco\u00a0Dindo,\u00a0Sandra M.\u00a0Correa,\u00a0Adrian W.R.\u00a0Serohijos,\u00a0Paola\u00a0Laurino,\u00a0Yariv\u00a0Brotman,\u00a0& Shimon\u00a0Bershtein. Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism. Nat Commun 15, 5285 (2024). https:\/\/doi.org\/10.1038\/s41467-024-49646-7<\/p>\n<\/div>

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Gencel M, Cofino GM, Hui C, Gauthier L, Tsang D, Philpott D, Ramathan S, Menendez A, Bershtein S, & Serohijos AWR (2023). Intra- and inter-species interactions drive early phases of invasion in mice gut microbiota. Biorxiv. doi: https:\/\/doi.org\/10.1101\/2022.12.30.522336<\/p>\n<\/blockquote>\n<\/div>\n<\/div>\n\n\n\n

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Shaferman M, Gencel M, Alon N, Alasad K, Rotblat B, Tsang D, Serohijos AWR, Alfonta L, & Bershtein S (2023). The fitness effects of codon composition of the horizontally transferred antibiotic resistance genes intensify at sub-lethal antibiotic levels. Mol Biol Evo. 40(6): ahead of print<\/p>\n<\/div>

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Stein D, Slobodnik Z, Tam B, Einav M, Akabayov B, BersteinS<\/strong>, ToiberPI<\/sup> D (2022). 4-phenylbutyric acid-Identity crisis; can it act as a translation inhibitor? Aging Cell<\/em>. 21:e13738 <\/p>\n<\/blockquote>\n\n\n\n

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Simon-Baram H, Roth S Z, Niedermayer C, Huber P, Speck M, Diener J, Richter M & Bershtein S. (2022). A high-throughput continuous spectroscopic assay to measure the activity of natural product methyltransferases. ChemBioChem. 4: e202200162<\/p>\n<\/blockquote>\n\n\n\n

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Kleiner D, Shapiro Tuchman Z Shmulevich F, Zarivach R, Shahar A, Kosloff M, & BershteinPI S. (2022). Evolution of homo-oligomerization of methionine S-adenosyltransferase is replete with structure-function constraints. Protein Sci. 31: e4352 doi:10.1002\/pro.4352. https:\/\/pubmed.ncbi.nlm.nih.gov\/35762725\/<\/a><\/p>\n<\/div>

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Bershtein, S., Kleiner, D. & Mishmar, D. Predicting 3D protein structures in light of evolution. Nat. Ecol. Evol.<\/em> 5<\/strong>, 1195\u20131198 (2021). https:\/\/www.nature.com\/articles\/s41559-021-01519-8<\/a><\/p>\n<\/div>

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Simon-Baram H, Kleiner D, Shmulevich F, Zarivach R, Zalk R, Tang H, Ding F, & Bershtein S. (2021). SAMase of bacteriophage T3 inactivates E. coli’s methionine S-adenosyltransferase by forming hetero-polymers. mBIO. 12: e01242-21 https:\/\/pubmed.ncbi.nlm.nih.gov\/34340545\/<\/a><\/p>\n<\/div>

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Bhattacharyya, S., Bershtein, S., Adkar, B. V, Woodard, J. & Shakhnovich, E. I.  Metabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype. Mol. Syst. Biol.<\/em> 17<\/strong>, 1\u201319 (2021). https:\/\/pubmed.ncbi.nlm.nih.gov\/34180142\/<\/a><\/p>\n<\/blockquote>\n\n\n\n

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Galai G, Ben-David H, Levin L, Orth M. F, Gr\u00fcnewald T, Pilosof S, & Bershtein S, & Rotblat, B. (2020) Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning. Cancers, 12: 825-838<\/p>\n<\/blockquote>\n\n\n\n

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Jasinska W, Manhart M, Lerner J, Gauthier L, Serohijos AWR, B. S. Chromosomal barcoding of E. coli populations reveals lineage diversity dynamics at high resolution. Nat. Ecol. Evol.<\/em> 4<\/strong>, 437\u2013452 (2020). https:\/\/www.nature.com\/articles\/s41559-020-1103-z<\/a><\/p>\n<\/div>

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Kleiner D, Shmulevich F, Zarivach R, Shahar A, Sharon M, Ben-Nissan G, Bershtein S. The interdimeric interface controls function and stability of Ureaplasma urealiticum methionine S-adenosyltransferase. J Mol Biol. 2019 Dec 6;431(24):4796-4816. doi: 10.1016\/j.jmb.2019.09.003. Epub 2019 Sep 12. https:\/\/pubmed.ncbi.nlm.nih.gov\/31520601\/<\/a><\/p>\n<\/div>

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Bershtein, S., Serohijos, A. W. & Shakhnovich, E. I. Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations. Curr. Opin. Struct. Biol.<\/em> 42<\/strong>, 31\u201340 (2017). https:\/\/pubmed.ncbi.nlm.nih.gov\/27810574\/<\/a><\/p>\n<\/blockquote>\n\n\n\n

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Bhattacharyya, S., Bershtein, S. & Shakhnovich, E. I. Gene Dosage Experiments in Enterobacteriaceae Using Arabinose-regulated Promoters. Bio-Protocol<\/em> 7<\/strong>, 1\u20136 (2017). https:\/\/pubmed.ncbi.nlm.nih.gov\/29170750\/<\/a><\/p>\n<\/blockquote>\n\n\n\n

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Bershtein S, Bhattacharyya S, Yan J, Argun T, Gilson AI, Trauger S, & Shakhnovich EI. (2016) Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity. eLife. pii: e20309 doi: 10.7554\/eLife.20309<\/p>\n<\/blockquote>\n\n\n\n

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RodriguesJV, Bershtein S, Li A, Lozovsky E, Hartl DL, & Shakhnovich EI. (2016). Biophysical principles predict fitness landscapes of drug resistance. PNAS. 113(11): E1470-8<\/p>\n<\/blockquote>\n\n\n\n

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Bershtein S, Serohijos AWR, Bhattacharyya S, Manhart M, Choi J-M, Mu W, Zhou J, & Shakhnovich EI. (2015) Protein homeostasis imposes a barrier on functional integration of horizontally transferred genes in bacteria. PloS Genet. 11(10): e1005612.<\/p>\n<\/blockquote>\n\n\n\n

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Palmer AC, Toprak E, Baym M.S, Kim S, Veres A, BershteinC S & KishonyPI R. (2015) Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes. Nat Commun. 6: 7385-7392.<\/p>\n<\/blockquote>\n\n\n\n

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Bershtein S, Choi J-M, Bhattacharyya S, Budnik B, & Shakhnovich IE. (2015) Systems-level response to point mutations in a core metabolic enzyme modulates genotype-phenotype relationship. Cell Rep. 11: 645-56.<\/p>\n<\/blockquote>\n\n\n\n

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Bershtein S, Mu W, Serohijos A.W, Zhou J, & Shakhnovich IE. (2013) Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness. Mol Cell. 49: 133-44. 7.<\/p>\n<\/blockquote>\n\n\n\n

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Bershtein S, Mu W & Shakhnovich IE. (2012) Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations. PNAS. 109: 4857-4862.<\/p>\n<\/blockquote>\n\n\n\n

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Bershtein S & Tawfik DS. (2008) Advances in laboratory evolution of enzymes. Curr Opin Chem Biol. 12: 151-158.<\/p>\n<\/blockquote>\n\n\n\n

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Bershtein S & Tawfik DS. (2008) Ohno\u2019s model revisited: Measuring the frequency of potentially adaptive mutations under various mutational drifts. Mol Biol Evol. 25: 2311-2318.<\/p>\n<\/blockquote>\n\n\n\n

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Bershtein S, Goldin K & Tawfik DS. (2008) Intense neutral drifts yield robust and evolvable consensus proteins. J Mol Biol. 379: 1029-1044<\/p>\n<\/blockquote>\n<\/div>\n\n\n\n

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Bershtein S, Segal M, Bekerman R, Tokuriki N & Tawfik DS. (2006) Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.<\/p>\n\n\n\n

Nature. 444: 929-932.<\/p>\n<\/blockquote>\n<\/div>\n\n\n\n

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Weronika\u00a0Jasinska,\u00a0Mirco\u00a0Dindo,\u00a0Sandra M.\u00a0Correa,\u00a0Adrian W.R.\u00a0Serohijos,\u00a0Paola\u00a0Laurino,\u00a0Yariv\u00a0Brotman,\u00a0& Shimon\u00a0Bershtein. Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism. Nat Commun 15, 5285 (2024). https:\/\/doi.org\/10.1038\/s41467-024-49646-7 Gencel M, Cofino GM, Hui C, Gauthier L, Tsang D, Philpott D, Ramathan S, Menendez A, Bershtein S, & Serohijos AWR (2023). Intra- and inter-species interactions drive early phases of invasion in mice gut […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-36","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/index.php?rest_route=\/wp\/v2\/pages\/36","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=36"}],"version-history":[{"count":47,"href":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/index.php?rest_route=\/wp\/v2\/pages\/36\/revisions"}],"predecessor-version":[{"id":567,"href":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/index.php?rest_route=\/wp\/v2\/pages\/36\/revisions\/567"}],"wp:attachment":[{"href":"https:\/\/lifewp.bgu.ac.il\/wp\/shimonb\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=36"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}