Scientific Publications

Scientific publications

Partial list, since 2015

  1. Ilouz, O., Cohen, S., Khalaila, I., 2024. A protein chimera for dsRNA binding and delivery into oocytes for large-scale gene silencing in crustacean aquaculture. Aquaculture, 740321.
  2. Cohen, S., Hasan, M., Frishman-Martsiano, N., Khalaila, I., 2023. A crustacean vitellogenin-derived peptide as an oocyte-specific delivery vehicle for gene silencing. Frontiers in Marine Science, https://doi:10.3389/fmars.2023.1128524.
  3. Ben-Naim, L, Khalaila, I, Papo, N., 2022. Modifying pH-sensitive PCSK9/LDLR interactions as a strategy to enhance hepatic cell uptake of low-density lipoprotein cholesterol (LDL-C). Protein Engineering Design and Selection, 35:1-14.
  4. Cohen, S., Ilouz, O., Manor, R., Sagi, A., Khalaila, I., 2021. Transcriptional silencing of vitellogenesis-inhibiting and molt-inhibiting hormones in the giant freshwater prawn, Macrobrachium rosenbergii, and evaluation of the associated effects on ovarian development. Aquaculture, 538: 736540.
  5. Abehsera, S., Bentov, S., Li, X., Weil, S., Manor, R., Sagi, S., Li, S., Li, F., Khalaila, I., Aflalo, E.D., & Sagi, A., 2021. Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans. Scientific reports, 11: 11722.
  6. Losev, Y., Frenkel-Pinter, M., Abu Hussien, M., Guru Krishna Kumar, V., Elyashiv Revivo, D., Geries, R., Khalaila, I., Gazit, E., Segal, D., 2021. Differential effects of putative N-glycosylation sites in human Tau on Alzheimer’s disease-related neurodegeneration. Cellular and Molecular Life Sciences, 78: 2231–2245.
  7. Makover, V., Ronen, Z., Loben, Y., Khalaila, I., 2019. Eggshell Spheres Protect Brown Widow Spider (Latrodectus geometricus) Eggs from Bacterial Infection. Journal of the Royal Society Interface, 16, http://doi.org/10.1098/rsif.2018.0581.
  8. Losev, Y., Paul, A., Frenkel-Pinter, M., Abu-Hussein, M., Khalaila, I.,  Gazit, E., Segal, D ., 2019. Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity. Scientific reports, 9:2254.
  9. Ben Harosh-Davidovich, S., and Khalaila, I., 2018. O-GlcNAcylation affects β-catenin and E-cadherin Expression, Cell Motility and Tumorigenicity of Colorectal Cancer. Experimental Cell Research, 364:42-49.
  10. Shenkman, M., Ron, E., Yehuda, R., Benyair, R., Khalaila, I., and Lederkremer, G. Z., 2018. Mannosidase activity of EDEM1 and EDEM2 depends on an unfolded state of their glycoprotein substrates. Communications Biology, 1:172.
  11. Abehsera, S., Zaccai, S., Mittelman, B., Glazer, L., Weil, S., Khalaila, I., Davidov, G., Bitton, R., Zarivach, R., Li, S., Li, F., Xiang, J., Manor, R.,  Aflalo, E. D., and Sagi, A., 2018. CPAP3 proteins in the mineralized cuticle of a decapod crustacean. Scientific reports, 8:2430
  12. Koren, S., and Khalaila, I., 2017. Effect of O-GlcNAcylation on hnRNP A1 translocation and interaction with transportin1. Experimental Cell Research, 350:210-217.
  13. Elharar, Y., Roth, Z., Rotkopf, R., Khalaila, I., and Gur, E., 2016. Post-translational regulation of coordinated enzyme activities in the Pup-proteasome system. PNAS, 113(12): E1605-E1614.
  14. Sharabi, O., Manor, R., Weil, S., Aflalo, E.D., Lezer, Y., Levy, T., Aizen, J., Ventura, T., Mather, P.B., Khalaila, I., and Sagi A., 2016. Identification and characterization of an insulin-like receptor involved in crustacean reproduction. Endocrinology, 157(2): 928-941.
  15. Glasner, A., Roth, Z., Varvak, A., Miletic, A., Isaacson, B., Bar-On, Y., Jonjic, S., Khalaila, I., Mandelboim, O., 2015. Identification of novel O glycosylations in the NK killer receptor Ncr1 essential for its activity. Cell Discovery, doi:10.1038/celldisc.2015.36.
  16. Glasner, A., Simic, H., Miklic, K., Roth, Z., Khalaila, I., Jonjic, S., Mandelboim, O., 2015. Expression, function and molecular properties of the killer receptor Ncr1-Noé. Journal of Immunology, 195:3959-3969.
  17. Tynyakov, J. S., Bentov, S., Abehsera, S., Yehezkel, G., Roth, Z., Khalaila, I., Weil, S., Berman, A., Plaschkes, I., Tom, M., and Sagi, A., 2015. A multi-task protein from the crayfish molar tooth able to bind chitin, nucleate apatite and catalyze calcium carbonate precipitation. J. Exp. Biol., doi: 10.1242/jeb.123539.
  18. Srivastava, S. K., Verma R., Khalaila, I., Gupta, B. D., Abdulhalim, I., 2015. SPR Based Fiber Optic Sensor for the Detection of Vitellogenin: An Endocrine Disruption Biomarker in Aquatic Environments, Biosens. J. 4:114. doi: 10.4172/2090-4967.1000114.
  19. Regev, O., Roth, Z., Korman, M., Khalaila, I., and Gur, E., 2015. A kinetic model for the prevalence of mono- over poly-pupylation, FEBS J., 282(21):4176-86.
  20. Glazer, L., Roth, Z., Weil, S., Aflalo, E., Khalaila, I., Sagi, A., 2015. Proteomic analysis of the crayfish gastrolith chitinous extracellular matrix reveals putative protein complexes and a central role for GAP 65. J. Proteomics, 128:333–343.
  21. Mayzlish-Gati, E., Laufer, D., Shaknof, J., Senans, A., Bir1, A., Ben-Harosh, S., Genin, O., Belausov, E., Grivas, F.,  D. Johnson, M., Yarden, R. I., Artuso, E., Prandi, C., Khalaila, I., Pines, M., Kapulnik, Y., and Koltai, H., 2015. Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model. Cancer Biology & Therapy, 16(11):1682-1688.
  22. Tynyakov, J. S., Bentov, S., Abehsera, S., Khalaila, I., Manor, R., Kazir, L., Weil, S., Eliahu, D.A., and Sagi, A., 2015. A novel chitin binding crayfish molar tooth protein with elasticity properties. PLOS one, 26:10(5):e0127871.
  23. Abehsera, S., Glazer, L., Tynyakov, J., Plashke, I., Caspi, V., Khalaila, I., Aflalo, E.D., Sagi, A., 2015. Binary gene expression patterning of the molt cycle: The case of chitin metabolism, PLOS one, 12;10(6):e0130787.