{"id":312,"date":"2024-05-29T18:54:11","date_gmt":"2024-05-29T15:54:11","guid":{"rendered":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/?page_id=312"},"modified":"2025-04-16T12:52:06","modified_gmt":"2025-04-16T09:52:06","slug":"about-franks-lab","status":"publish","type":"page","link":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/","title":{"rendered":"About"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"312\" class=\"elementor elementor-312\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e04f62b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e04f62b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-375d8d3\" data-id=\"375d8d3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fb8f97c elementor-widget elementor-widget-heading\" data-id=\"fb8f97c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">About<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-021116f elementor-widget elementor-widget-text-editor\" data-id=\"021116f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<h4>Proteins are remarkably fine-tuned molecular machines, precisely sensing and responding to their environment. Our lab aims to decipher the structural and functional mechanisms that enable this dynamic decision-making, with the broader goal of applying these insights to artificial protein design. To achieve this, we focus on two contrasting model systems: the highly flexible AAA+ ATPase from Mycobacteria, which drives protein degradation, and the structurally rigid iron-storage protein ferritin, along with the dynamic network of flexible and disordered proteins that regulate its fate in the cell. By integrating Cryo-EM with functional assays, we unravel how these molecular machines operate at atomic resolution. Our interdisciplinary team\u2014bringing together biologists, chemists, and physicists\u2014fosters a collaborative atmosphere where members develop both intellectually and technically. The lab is also a key contributor to advancing Cryo-EM as a major scientific resource for the Israeli research community.<\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0e4d728 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0e4d728\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-496b6ff\" data-id=\"496b6ff\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-cdb3b03 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cdb3b03\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-2531700\" data-id=\"2531700\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-57f8989 elementor-widget__width-initial elementor-widget elementor-widget-sp_wp_carousel_shortcode\" data-id=\"57f8989\" data-element_type=\"widget\" data-widget_type=\"sp_wp_carousel_shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t <style id=\"wp_carousel_dynamic_css563\">#sp-wp-carousel-free-id-563.sp-wpcp-563 .wpcp-single-item {border: 1px solid #dddddd;}#sp-wp-carousel-free-id-563.sp-wpcp-563 .swiper-button-prev,#sp-wp-carousel-free-id-563.sp-wpcp-563 .swiper-button-next,#sp-wp-carousel-free-id-563.sp-wpcp-563 .swiper-button-prev:hover,#sp-wp-carousel-free-id-563.sp-wpcp-563 .swiper-button-next:hover {background: none;border: none;font-size: 30px;}#sp-wp-carousel-free-id-563.sp-wpcp-563 .swiper-button-prev i,#sp-wp-carousel-free-id-563.sp-wpcp-563 .swiper-button-next i {color: #aaa;}#sp-wp-carousel-free-id-563.sp-wpcp-563 .swiper-button-prev i:hover,#sp-wp-carousel-free-id-563.sp-wpcp-563 .swiper-button-next i:hover {color: #178087;}#sp-wp-carousel-free-id-563.sp-wpcp-563 .wpcp-swiper-dots .swiper-pagination-bullet {background-color: #cccccc;}#sp-wp-carousel-free-id-563.sp-wpcp-563 .wpcp-swiper-dots .swiper-pagination-bullet.swiper-pagination-bullet-active {background-color: #178087;} #sp-wp-carousel-free-id-563.sp-wpcp-563.wpcp-image-carousel .wpcp-single-item:hover img, #sp-wp-carousel-free-id-563.sp-wpcp-563.wpcp-post-carousel .wpcp-single-item:hover img, #sp-wp-carousel-free-id-563.sp-wpcp-563.wpcp-product-carousel .wpcp-single-item:hover img{-webkit-transform: scale(1.2);-moz-transform: scale(1.2);transform: scale(1.2);}#sp-wp-carousel-free-id-563 .wpcpro-row>[class*=\"wpcpro-col-\"] { padding: 0 10px; padding-bottom: 20px;}@media (min-width: 480px) { .wpcpro-row .wpcpro-col-sm-1 { flex: 0 0 100%; max-width: 100%; } .wpcpro-row .wpcpro-col-sm-2 { flex: 0 0 50%; max-width: 50%; } .wpcpro-row .wpcpro-col-sm-2-5 { flex: 0 0 75%; max-width: 75%; } .wpcpro-row .wpcpro-col-sm-3 { flex: 0 0 33.333%; max-width: 33.333%; } .wpcpro-row .wpcpro-col-sm-4 { flex: 0 0 25%; max-width: 25%; } .wpcpro-row .wpcpro-col-sm-5 { flex: 0 0 20%; max-width: 20%; } .wpcpro-row .wpcpro-col-sm-6 { flex: 0 0 16.66666666666667%; max-width: 16.66666666666667%; } .wpcpro-row .wpcpro-col-sm-7 { flex: 0 0 14.28571428%; max-width: 14.28571428%; } .wpcpro-row .wpcpro-col-sm-8 { flex: 0 0 12.5%; max-width: 12.5%; } } @media (max-width: 480px) { .wpcpro-row .wpcpro-col-xs-1 { flex: 0 0 100%; max-width: 100%; } .wpcpro-row .wpcpro-col-xs-2 { flex: 0 0 50%; max-width: 50%; } .wpcpro-row .wpcpro-col-xs-3 { flex: 0 0 33.222%; max-width: 33.222%; } .wpcpro-row .wpcpro-col-xs-4 { flex: 0 0 25%; max-width: 25%; } .wpcpro-row .wpcpro-col-xs-5 { flex: 0 0 20%; max-width: 20%; } .wpcpro-row .wpcpro-col-xs-6 { flex: 0 0 16.6667%; max-width: 16.6667%; } .wpcpro-row .wpcpro-col-xs-7 { flex: 0 0 14.28571428%; max-width: 14.28571428%; } .wpcpro-row .wpcpro-col-xs-8 { flex: 0 0 12.5%; max-width: 12.5%; } } @media (min-width: 736px) { .wpcpro-row .wpcpro-col-md-1 { flex: 0 0 100%; max-width: 100%; } .wpcpro-row .wpcpro-col-md-2 { flex: 0 0 50%; max-width: 50%; } .wpcpro-row .wpcpro-col-md-2-5 { flex: 0 0 75%; max-width: 75%; } .wpcpro-row .wpcpro-col-md-3 { flex: 0 0 33.333%; max-width: 33.333%; } .wpcpro-row .wpcpro-col-md-4 { flex: 0 0 25%; max-width: 25%; } .wpcpro-row .wpcpro-col-md-5 { flex: 0 0 20%; max-width: 20%; } .wpcpro-row .wpcpro-col-md-6 { flex: 0 0 16.66666666666667%; max-width: 16.66666666666667%; } .wpcpro-row .wpcpro-col-md-7 { flex: 0 0 14.28571428%; max-width: 14.28571428%; } .wpcpro-row .wpcpro-col-md-8 { flex: 0 0 12.5%; max-width: 12.5%; } } @media (min-width: 980px) { .wpcpro-row .wpcpro-col-lg-1 { flex: 0 0 100%; max-width: 100%; } .wpcpro-row .wpcpro-col-lg-2 { flex: 0 0 50%; max-width: 50%; } .wpcpro-row .wpcpro-col-lg-3 { flex: 0 0 33.222%; max-width: 33.222%; } .wpcpro-row .wpcpro-col-lg-4 { flex: 0 0 25%; max-width: 25%; } .wpcpro-row .wpcpro-col-lg-5 { flex: 0 0 20%; max-width: 20%; } .wpcpro-row .wpcpro-col-lg-6 { flex: 0 0 16.6667%; max-width: 16.6667%; } .wpcpro-row .wpcpro-col-lg-7 { flex: 0 0 14.28571428%; max-width: 14.28571428%; } .wpcpro-row .wpcpro-col-lg-8 { flex: 0 0 12.5%; max-width: 12.5%; } } @media (min-width: 1200px) { .wpcpro-row .wpcpro-col-xl-1 { flex: 0 0 100%; max-width: 100%; } .wpcpro-row .wpcpro-col-xl-2 { flex: 0 0 50%; max-width: 50%; } .wpcpro-row .wpcpro-col-xl-3 { flex: 0 0 33.22222222%; max-width: 33.22222222%; } .wpcpro-row .wpcpro-col-xl-4 { flex: 0 0 25%; max-width: 25%; } .wpcpro-row .wpcpro-col-xl-5 { flex: 0 0 20%; max-width: 20%; } .wpcpro-row .wpcpro-col-xl-6 { flex: 0 0 16.66667%; max-width: 16.66667%; } .wpcpro-row .wpcpro-col-xl-7 { flex: 0 0 14.28571428%; max-width: 14.28571428%; } .wpcpro-row .wpcpro-col-xl-8 { flex: 0 0 12.5%; max-width: 12.5%; } }<\/style><div class=\"wpcp-carousel-wrapper wpcp-wrapper-563\">\n\t<div id=\"wpcp-preloader-563\" class=\"wpcp-carousel-preloader\"><img decoding=\"async\" src=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/plugins\/wp-carousel-free\/public\/css\/spinner.svg\" alt=\"Preloader Image\" \/><\/div>\t<div class=\"wpcp-carousel-content-wrapper\">\n\t<div id=\"sp-wp-carousel-free-id-563\" class=\"wpcp-carousel-section sp-wpcp-563  nav-vertical-center wpcp-image-carousel wpcp-preloader wpcp-standard\" data-swiper='{ &quot;accessibility&quot;:true, &quot;spaceBetween&quot;:20, &quot;arrows&quot;:true, &quot;freeMode&quot;: false, &quot;autoplay&quot;:true, &quot;autoplaySpeed&quot;:3700, &quot;dots&quot;:true, &quot;infinite&quot;:true, &quot;speed&quot;:600, &quot;pauseOnHover&quot;:true,\n\t\t\t&quot;slidesToShow&quot;:{&quot;lg_desktop&quot;:3, &quot;desktop&quot;: 3, &quot;laptop&quot;: 3, &quot;tablet&quot;: 2, &quot;mobile&quot;: 1}, &quot;responsive&quot;:{&quot;desktop&quot;:1200, &quot;laptop&quot;: 980, &quot;tablet&quot;: 736, &quot;mobile&quot;: 480}, &quot;rtl&quot;:false, &quot;lazyLoad&quot;: &quot;false&quot;, &quot;swipe&quot;: true, &quot;draggable&quot;: true, &quot;swipeToSlide&quot;:false }' dir=\"ltr\">\n\t\t<div class=\"swiper-wrapper\">\n\t\t<div class=\"swiper-slide\">\n\t<div class=\"wpcp-single-item\">\n\t\t\t<a class=\"wcp-light-box\" data-buttons='[\"close\"]' data-wpc_url='https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/2-300x300.png' href=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/2-300x300.png\" data-fancybox=\"wpcp_view\">\n\t\t<figure>\n\t\t\t<img fetchpriority=\"high\" decoding=\"async\" class=\"skip-lazy\" src=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/2-300x300.png\" alt=\"2\" width=\"300\" height=\"300\">\t\t<\/figure>\n\t<\/a>\n\t\t<\/div>\n<\/div>\n\t<div class=\"swiper-slide\">\n\t<div class=\"wpcp-single-item\">\n\t\t\t<a class=\"wcp-light-box\" data-buttons='[\"close\"]' data-wpc_url='https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/1-300x300.png' href=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/1-300x300.png\" data-fancybox=\"wpcp_view\">\n\t\t<figure>\n\t\t\t<img decoding=\"async\" class=\"skip-lazy\" src=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/1-300x300.png\" alt=\"1\" width=\"300\" height=\"300\">\t\t<\/figure>\n\t<\/a>\n\t\t<\/div>\n<\/div>\n\t<div class=\"swiper-slide\">\n\t<div class=\"wpcp-single-item\">\n\t\t\t<a class=\"wcp-light-box\" data-buttons='[\"close\"]' data-wpc_url='https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/07\/Hoelzgen_NatureComm_1-300x288.png' href=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/07\/Hoelzgen_NatureComm_1-300x288.png\" data-fancybox=\"wpcp_view\">\n\t\t<figure>\n\t\t\t<img decoding=\"async\" class=\"skip-lazy\" src=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/07\/Hoelzgen_NatureComm_1-300x288.png\" alt=\"Hoelzgen_NatureComm_1\" width=\"300\" height=\"288\">\t\t<\/figure>\n\t<\/a>\n\t\t<\/div>\n<\/div>\n\t<div class=\"swiper-slide\">\n\t<div class=\"wpcp-single-item\">\n\t\t\t<a class=\"wcp-light-box\" data-buttons='[\"close\"]' data-wpc_url='https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/4-300x300.png' href=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/4-300x300.png\" data-fancybox=\"wpcp_view\">\n\t\t<figure>\n\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"skip-lazy\" src=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/4-300x300.png\" alt=\"4\" width=\"300\" height=\"300\">\t\t<\/figure>\n\t<\/a>\n\t\t<\/div>\n<\/div>\n\t<div class=\"swiper-slide\">\n\t<div class=\"wpcp-single-item\">\n\t\t\t<a class=\"wcp-light-box\" data-buttons='[\"close\"]' data-wpc_url='https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/6-300x300.png' href=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/6-300x300.png\" data-fancybox=\"wpcp_view\">\n\t\t<figure>\n\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"skip-lazy\" src=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/6-300x300.png\" alt=\"6\" width=\"300\" height=\"300\">\t\t<\/figure>\n\t<\/a>\n\t\t<\/div>\n<\/div>\n\t<div class=\"swiper-slide\">\n\t<div class=\"wpcp-single-item\">\n\t\t\t<a class=\"wcp-light-box\" data-buttons='[\"close\"]' data-wpc_url='https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/3-300x300.png' href=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/3-300x300.png\" data-fancybox=\"wpcp_view\">\n\t\t<figure>\n\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"skip-lazy\" src=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/3-300x300.png\" alt=\"3\" width=\"300\" height=\"300\">\t\t<\/figure>\n\t<\/a>\n\t\t<\/div>\n<\/div>\n\t<div class=\"swiper-slide\">\n\t<div class=\"wpcp-single-item\">\n\t\t\t<a class=\"wcp-light-box\" data-buttons='[\"close\"]' data-wpc_url='https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/5-300x300.png' href=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/5-300x300.png\" data-fancybox=\"wpcp_view\">\n\t\t<figure>\n\t\t\t<img loading=\"lazy\" decoding=\"async\" class=\"skip-lazy\" src=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/wp-content\/uploads\/2024\/08\/5-300x300.png\" alt=\"5\" width=\"300\" height=\"300\">\t\t<\/figure>\n\t<\/a>\n\t\t<\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"wpcp-swiper-dots swiper-pagination\"><\/div>\n\t\t\t\t<!-- If we need navigation buttons -->\n\t\t\t\t\t<div class=\"wpcp-prev-button swiper-button-prev\"><i class=\"fa fa-angle-left\"><\/i><\/div>\n\t\t\t<div class=\"wpcp-next-button swiper-button-next\"><i class=\"fa fa-angle-right\"><\/i><\/div>\n\t\t\t<\/div>\n\t<\/div>\n<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a108f8 elementor-widget elementor-widget-heading\" data-id=\"3a108f8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Model Systems<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d0ee96 elementor-widget elementor-widget-text-editor\" data-id=\"4d0ee96\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h4><span style=\"color: #1f3c47;\">Our lab focuses on two complementary model systems that illustrate how proteins integrate environmental signals to make functional decisions:<\/span><\/h4><h4><span style=\"color: #1f3c47; font-size: 1.125rem;\">AAA+ ATPases<\/span><span style=\"color: #1f3c47; font-size: 1.125rem;\">\u00a0<br \/>\u00a0 We study Mpa, the proteasomal ATPase of Mycobacteria. Mpa is a highly dynamic molecular machine that orchestrates substrate identification, unfolding, and translocation into the 20S proteasome. This system exemplifies how proteins integrate mechanical, structural, and nucleotide-derived signals to regulate substrate processing\u2014a key decision in proteostasis.<br \/><\/span><span style=\"color: #1f3c47; font-size: 1.125rem;\">\u00a0 Mpa is essential for the survival and virulence of M. tuberculosis, making it a promising target for novel antibacterial strategies.<\/span><\/h4><h4><span style=\"color: #1f3c47;\">Iron Homeostasis<br \/><\/span><span style=\"color: #1f3c47; font-size: 1.125rem;\">\u00a0 We investigate the iron-storage protein ferritin and its regulation by the adaptor protein NCOA4 and the E3 ubiquitin ligase HERC2, which together form the Ferritin\u2013NCOA4\u2013HERC2 iron regulatory circuit. This network controls ferritin degradation in response to fluctuations in intracellular iron levels and redox state, integrating metabolic, oxidative, and signaling cues to regulate iron availability.<br \/><\/span><span style=\"color: #1f3c47; font-size: 1.125rem;\">\u00a0 Dysregulation of this circuit is implicated in conditions such as neurodegeneration, anemia, and cancer, underscoring its importance in both cellular function and human health.<\/span><\/h4>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>About Proteins are remarkably fine-tuned molecular machines, precisely sensing and responding to their environment. Our lab aims to decipher the structural and functional mechanisms that enable this dynamic decision-making, with the broader goal of applying these insights to artificial protein design. To achieve this, we focus on two contrasting model systems: the highly flexible AAA+ &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;About&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-312","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/index.php?rest_route=\/wp\/v2\/pages\/312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=312"}],"version-history":[{"count":92,"href":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/index.php?rest_route=\/wp\/v2\/pages\/312\/revisions"}],"predecessor-version":[{"id":939,"href":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/index.php?rest_route=\/wp\/v2\/pages\/312\/revisions\/939"}],"wp:attachment":[{"href":"https:\/\/lifewp.bgu.ac.il\/wp\/frankg\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}