Facilities

The Macromolecular Crystallography Research Center has a state of the art facilities for setting up highthroughput crystallization experiments with a nano-liter volume of samples and for storing and monitoring the crystallization experiments at various temperatures.

MarµX X-ray System (MarResearch)
A complete home source for X-ray crystallography, which includes a state-of-the-art micro beam sealed tube generator with a specially designed high-performance optics, a mardtb “desktop beamline” and a mar345 mar345smar345= image plate detector, as well as cryogenic cooling system.  to it plus a cryo-cooler
Specifications:
Generator – 30 Watts (50 kV, 600 mA)
Detector – mar345 image plate detector with 345 mm diameter
Gonistat – mardtb “desktop beamline” with easymount
Cryo cooler – Oxford Cryosystems
Beam size at sample: ≤ 250 x 250 μm
Beam divergence: ≤ 5 x 5 mrad2
Total flux: > 6 x 108 photons/sec
Peak flux density at focal spot: > 1 x 1010 photons/sec/mm2
Focal distance: 600 mm from source
Anode cooling: air-cooling by fan
Mirror protection: diaphragm vacuum pump with interlock to shutter
Rock Maker (Formulatrix)
Powerful software which provides the experimental design and which automates and tracks the crystallization process. It allows for the rapid creation of complex experiments and crystallization
screens in a user-friendly environment.
Formulator (Formulatrix)
A liquid handler that dispenses crystallization solutions for 24- as well as for 96-well grids rapidly and with high accuracy.
   
NT8 Drop Setter (Formulatrix)
A fast and precise automated nanoliter dispenser for setting up crystallization experiments including sitting drops, hanging drops and seeding.
Rock Imager (Formulatrix)
An automated imaging system for protein crystallization. This apparatus incubates and captures quality images of up to 250 crystallization plates on a user-defined schedule.

Rock Maker Web (Formulatrix)
Website for users to follow up on the crystallization experiments

Computing Facilities
The MCRC has various workstations running under Linux operating system. Commonely crystallographic softwares for all the stages of a crystal structure determination (data collection, processing, phasing, refinement, molecular graphics, structure analysis and validation) and modelling are available for users to process and analyze their data.